# Scientist II, Biomolecular Characterization at Bighatbiosciences

> Onsite · United States · Mid-level · Other · open. Source: https://alderhq.app/jobs/pinpoint%3Abighatbiosciences%3A570862 (read 2026-11-07).

## Facts (observed)

- Company: [Bighatbiosciences](https://alderhq.app/companies/bighatbiosciences)
- Location text: San Mateo, CA, CA
- Where it can be done from (inferred): Onsite · United States (evidence: "Location: San Mateo, CA, CA")
- Posted: already open when tracking began; date unknown
- First seen by alder: 2026-11-04 · last verified: 2026-11-04
- Reposted: 0 times · edited: 0 times
- Apply on the employer's site: https://bighatbiosciences.pinpointhq.com/en/postings/9b5ebce7-90fd-475b-906d-37d32981eb2e

## Pay and sponsorship

- Posted pay: $145k–$165k per year (from the description)
- Market band for similar posted roles (SF Bay Area, n 92): p25 $112k, median $171k, p75 $231k

## Description (the employer's text)

The role: BigHat Biosciences is seeking an exceptional individual for a Scientist II or Senior Scientist I in Biomolecular Characterization\* role to drive characterization of in vitro antibody-target binding behavior, develop new assay capabilities, and represent the team across BigHat’s programs.

\*At BigHat we believe in titles that are commensurate with skill set, relative organizational impact, and value contribution; more or less experienced candidates are encouraged to apply, with the understanding that responsibilities and title would adjust as appropriate.

### Responsibilities

- Develop, optimize, and implement high- and low-throughput state-of-the-art strategies to characterize the interactions between antibody and antigen using biolayer interferometry (BLI) and surface plasmon resonance (SPR).
- Implement best practices for binding assay design across various bioanalytical assay formats.
- Troubleshoot and diagnose assay issues, building foundational understanding of antibody/antigen interactions that stakeholders can act on.
- Collaborate closely with BigHat’s science organization to accelerate hits from discovery through lead optimization and candidate nomination.
- Effectively synthesize and communicate results and research activity to key decision makers and the broader BigHat team.
- Partner with automation engineering, software engineering, and production teams to scale and productionize high-throughput kinetics assays.
### Skills

- Ph.D. 2-5 years, or M.Sc with 5+ years of independent research and development experience in an industry setting, including substantial experience with binding assays including BLI, SPR, ELISA/MSD and Flow Cytometry workflows (preferably across Carterra, Cytiva and Sartorius instrumentation).
- Practical and theoretical fluency in bioanalytical science, biochemistry, biophysics, assay design and development (experience in both complex and buffered matrices preferred).
- Experience with lab automation and working with automation engineers (preferred).
- Strong data analysis and interpretation skills coupled to exceptional written, verbal, and visual communication skills.
- Ability to educate and build consensus among diverse stakeholders regarding scientific direction.
### Benefits

The salary estimated for this position is $145,000 - $165,000 + bonus + options + benefits. Compensation will vary depending on job-related knowledge, skills, and experience. Actual compensation will be confirmed in writing at the time of the offer.

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Data: alder (https://alderhq.app). Cite https://alderhq.app/jobs/pinpoint%3Abighatbiosciences%3A570862 and the date you read it. Observed facts come from the employer's own listing; location reach, level, family and skills are inferences.