# Senior Scientist I, Antibody Engineering at Bighatbiosciences

> Onsite · United States · Senior · Other · open. Source: https://alderhq.app/jobs/pinpoint%3Abighatbiosciences%3A561241 (read 2026-11-14).

## Facts (observed)

- Company: [Bighatbiosciences](https://alderhq.app/companies/bighatbiosciences)
- Location text: San Mateo, CA, CA
- Where it can be done from (inferred): Onsite · United States (evidence: "Location: San Mateo, CA, CA")
- Posted: already open when tracking began; date unknown
- First seen by alder: 2026-11-04 · last verified: 2026-11-09
- Reposted: 0 times · edited: 0 times
- Apply on the employer's site: https://bighatbiosciences.pinpointhq.com/en/postings/f237fe02-5f68-47bc-8403-ba6502fd88f6

## Pay and sponsorship

- Posted pay: $160k–$185k per year (from the description)
- Market band for similar posted roles (SF Bay Area, n 659): p25 $130k, median $164k, p75 $195k

## Description (the employer's text)

The role: BigHat Biosciences is seeking an exceptional individual for a Senior Scientist I role on the antibody engineering & binder generation team to serve as a program team lead of therapeutic programs with external and internal partners, driving antibody discovery, design, optimization, and characterization.

### Responsibilities

- Lead cross-functional project teams (including Data Science, AI/ML, Engineering, Protein Sciences, Automation) on the execution of rapid, iterative multi-objective optimization to identify high-value therapeutic antibodies through gold-standard assays.
- Deeply understand target biology to better design antibodies that meet our candidate profile.
- Contribute expertise in antibody engineering approaches (including humanization, liability remediation, affinity tuning, format engineering, etc) to generate and optimize novel antibodies that meet design requirements.
- Collaborate closely with BigHat leadership and other cross-functional team members to ensure a tight linkage between strategy, research, and development components.
- Lead in-depth data analysis of each design cycle to better leverage experimental and computational approaches to reach our design goals.
- Effectively and regularly communicate results to key decision makers, the broader BigHat team, and to external partners.
### Skills

- Ph.D. in biochemistry, structural biology, protein engineering, or related fields.
- 5+ years of advanced research experience in an industry setting.
- Hands-on protein engineering expertise, including structure-guided design, affinity maturation, stability/developability optimization, and rational or computational approaches to antibody engineering.
- Experience working with diverse antibody formats such as complex multispecifics, T-cell engagers, antibody fragments, antibody-drug conjugates, etc.
- Expertise in mammalian cell culture, immunoassay, molecular techniques, cell-based assays, protein expression and characterization (e.g., kinetics, SEC).
- Exceptional written, verbal, and visual communication skills.
- Experience presenting and communicating strategy and results to internal and external partners.
- Scientific track record and publication record.
- Strong data analysis and interpretation skills. Experience working with agentic software tools is a plus.
### Benefits

The salary estimated for this position is $160,000 - $185,000 + bonus + options + benefits. Compensation will vary depending on job-related knowledge, skills, and experience. Actual compensation will be confirmed in writing at the time of the offer.

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Data: alder (https://alderhq.app). Cite https://alderhq.app/jobs/pinpoint%3Abighatbiosciences%3A561241 and the date you read it. Observed facts come from the employer's own listing; location reach, level, family and skills are inferences.