Sr Technical Product Owner (Hybrid in South San Francisco, CA)

About the Role

At Twist Bioscience, we're scaling the digital systems that power our synthetic DNA platform

and enable innovation across our commercial, scientific, and operational teams. We're seeking

a Senior Technical Product Owner to lead cross-functional system projects, someone who can

dive deep into the details while helping improve how we work.

In this role, you will own hands-on work across requirements gathering, documentation, and

testing for high-impact system initiatives. We are looking for someone with a proven track record

of maintaining effective business relationships to ensure IBT can deliver solutions that align with

business strategies and objectives. This role sits at the intersection of product, engineering,

and business.

The ideal candidate has a strong analytical mindset, solid experience with enterprise and

technical systems, and a knack for translating complex business and product needs into clear,

executable technical requirements.

What You will do

You will serve as the primary business-facing partner on system initiatives, owning the functional definition of what needs to be built and partnering closely with engineering and project management, who own technical design, delivery sequencing, and timelines.

Requirements and Solution definition

● Lead requirements intake and clarification with business stakeholders across functions

(e.g., Product, Marketing, Sales Operations, Finance, Customer Support, and R&D).

● Define and document functional requirements, business rules, edge cases, and

acceptance criteria, including impacted existing logic, constraints, and exceptions, and

translate them into epics and user stories ready for development and QA.

● Identify impacted process areas, systems, and dependencies end to end (e.g., product

setup, pricing, quoting, order intake, manufacturing, fulfillment, and invoicing), along with

the SMEs and stakeholders within each.

● Drive alignment with cross-system partners and SMEs to ensure requirements are

complete and consistent across integrated systems and address emerging business

needs, positioning the organization to stay ahead of new commercial requests.

● Ensure requirements and solutions are compliant and audit-ready (e.g., SOX, ISO),

partnering with Finance, Quality and other internal stakeholders.

● Demonstrate strong customer empathy and advocate for customer needs throughout the

product development process

Delivery partnership and communication

● Provide development leads, architects, and project managers with the full end-to-end

context and scope of each initiative, and lead functional grooming sessions.

● Partner with project management, scrum masters, developers, architecture, and SWQA

through design, build, testing, and delivery, clarifying requirements and surfacing risks,

gaps, and dependencies early.

● Communicate proactively and consistently with business stakeholders on scope, status,

risks, and dependencies throughout each initiative.

● Influence scope tradeoffs and solution options by bringing business and cross-system

context to technical discussions.

Testing, launch, and stabilization

● Plan and lead end-to-end user acceptance testing across multiple systems: kick off with

testers, provide context and demos, support issue logging and defect clarification, and

obtain stakeholder sign-off before go-live.

● Support release, hypercare, and post-launch stabilization, providing business context to

help assess the criticality of issues.

● Stay informed on production issues and contribute business and system context to their

resolution.

Continuous improvement

● Share feedback and ideas to continuously improve how the team runs projects, gathers

requirements, and tests, including intake playbooks, documentation standards, and

testing practices.

● Look for opportunities to leverage AI tools to work more efficiently, such as in

requirements documentation, analysis, and testing.

Qualifications

● Bachelor's degree in a technical, engineering, or scientific field; minimum of 5+ years of