# Lead Clinical Lab Scientist (3rd Shift, Tues-Sat) at Personalis

> United States · Staff · Other · open. Source: https://alderhq.app/jobs/greenhouse%3Apersonalisinc%3A8197153003 (read 2026-11-11).

## Facts (observed)

- Company: [Personalis](https://alderhq.app/companies/personalis)
- Location text: Fremont, CA; Fremont, CA
- Where it can be done from (inferred): United States (evidence: "Location: Fremont, CA; Fremont, CA")
- Posted: 2026-11-05 (6 days ago)
- First seen by alder: 2026-11-06 · last verified: 2026-11-09
- Reposted: 0 times · edited: 0 times
- Apply on the employer's site: https://job-boards.greenhouse.io/personalisinc/jobs/8197153003

## Pay and sponsorship

- Posted pay: not posted
- Market band for similar posted roles (SF Bay Area, n 913): p25 $175k, median $208k, p75 $250k
- H-1B filings at this company for similar roles, FY26: 2 ([US DOL OFLC LCA disclosure data](https://www.dol.gov/agencies/eta/foreign-labor/performance))

## Description (the employer's text)

At Personalis, we are transforming the active management of cancer through breakthrough personalized testing. We aim to drive a new paradigm for cancer management, guiding care from biopsy through the life of the patient. Our highly sensitive assays combine tumor-and-normal profiling with proprietary algorithms to deliver advanced insights even as cancer evolves over time. Our products are designed to detect minimal residual disease (MRD) and recurrence at the earliest timepoints, enable selection of targeted therapies based on ultra-comprehensive genomic profiling, and enhance biomarker strategy for drug development. Personalis is based in Fremont, California.

Shift Available:

- Tues-Sat 10pm - 6:30am
Training hours may be different from your shift schedule. The PM and 3rd shift would be eligible for an additional shift premium.

Summary:

A Lead Clinical Lab Scientist performs and reports on clinical laboratory testing that aids physicians in diagnosing and treating patients. A key part of the role is helping supervise team members and ensuring that all laboratory procedures are followed for specimen handling, next-generation sequencing (NGS) processes, test analyses, and the accurate maintenance of patient records.

In our lab, we foster a positive, friendly, and team-based environment. We all pitch in to achieve our common goals and support each other. You'll work in a dynamic atmosphere, with opportunities to gain hands-on experience at multiple benches, including extractions, library preparation, and sequencing. You'll also partner with our lab assistants to coordinate pre-analytical and post-analytical tasks.

Responsibilities:

- Perform and report clinical laboratory testing on patient samples to aid physicians diagnose and treat patients. This can include the following areas:
- Extractions
- Library Preparation
- Enrichments
- Handle and process all patient specimens according to laboratory procedures, ensuring accurate and timely record-keeping and reporting of results.
- Execute LIMS entry and review signoffs.
- Select, implement, and evaluate quality control materials for statistical process control of laboratory assays.
- Troubleshoot assays and equipment when quality control materials fail to perform as expected.
- Document all corrective actions taken when test systems deviate from established performance specifications.
- Work with Facilities to address building/facilities related issues that arise during their assigned shift to ensure minimal disruption to processing.
- Work with the OPS managers to report incidents and non-conformances into the Quality team.
- Assist in audits by regulatory bodies like CAP and external customers.
- Participate in activities that support the laboratory's necessary licensure, including quality management and on-site inspections.
- Responsible for maintaining updated understanding and knowledge of the methods employed in the laboratory and the use of the resulting information by physicians through continuing education activities.
- Identify and correct problems that may negatively affect test performance or result reporting. If a problem cannot be immediately corrected, notify a supervisor, clinical consultant, or director.
- Train other CLS and lab personnel on laboratory methods.
- Monitor the activities of non-licensed staff.
- As needed, oversee or supervise the activities of the laboratory in the absence of an onsite manager.
- Provide guidance to team members on troubleshooting and deviation investigations.
- Assist in assay development activities.
- Demonstrate strong analytical skills and independent critical thinking.
- Apply technical and functional knowledge to help the team meet its goals.
- Work independently to identify and resolve complex, open-ended problems.
Requirements:

- Education: Bachelor's degree, preferably in sciences or related discipline.
- Licensure: Valid California Clinical Laboratory Scientist (CLS) or Clinical Genetic Molecular Biologist Scientist (CGMBS) license.
- Experience: At least two years of CLS experience in a clinical laboratory environment. 4+ years total work experience in a laboratory preferred.

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Data: alder (https://alderhq.app). Cite https://alderhq.app/jobs/greenhouse%3Apersonalisinc%3A8197153003 and the date you read it. Observed facts come from the employer's own listing; location reach, level, family and skills are inferences.