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Lila Sciences

Principal Software Engineer, Applied AI

Cambridge, MA USA; San Francisco, CA USA; One Charles Park, Cambridge, MA; San Francisco, CAUnited States
Principal · Software
POSTED 6 OCT 2025VERIFIED 17H AGO
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Role
402 days opentrue age
Past the 83d median close
Posted 6 Oct 2025 · n=12
Payats field
$204k–310kposted
▲ +9% vs market median $235k
$115k$310k
Market p25–p75
$200k–$263k
Lila Sciences p25–p75
$210k–$257kn=6
H-1B median · Software engineering
$115k
Boston · n=41 · 365d to 12 Nov
CompanyLila Sciences →
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Closed · 30d
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2,632open · Principal Software engineering
Opened · 7d
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75,453open
All tracked boards · live 13 Nov · n=2,632
Visa
24H-1B LCAs · FY26
Median wage
$142k
LCAs FY26 · n=24 · to 2026-06-03
PythonDjangoFastAPIAWSKubernetesDockerTerraformSQLLLMsDistributed systems

Your Impact at LILA

We are seeking a Principal Software Engineer to join our Applied AI group and help build the next generation of our AI-driven scientific platform. In this role, you will design and optimize the backend systems, data pipelines, and AI integrations that power intelligent, data-driven applications. You’ll work at the intersection of backend engineering and machine learning, ensuring our platform seamlessly scales and supports cutting-edge applied AI techniques such as Retrieval-Augmented Generation (RAG), agentic AI, and large language model (LLM) integration.

This role is ideal for someone who thrives in bridging software engineering and applied AI—turning research into production-grade systems that drive real-world scientific discovery. If you are passionate about building performant, elegant systems that make AI useful and impactful, we would love to hear from you!

What You'll Be Building

  • Applied AI Integration: Design and deploy backend services and data pipelines that directly support advanced AI applications, including LLMs, RAG, and agentic frameworks.
  • API & Service Development: Build high-performance APIs and microservices that enable seamless integration between AI models, scientific tools, and user-facing applications.
  • Data Pipeline Architecture: Architect and manage scalable pipelines capable of handling structured, unstructured, and vectorized data for AI/ML workloads.
  • Database & Knowledge Systems: Implement and optimize SQL, NoSQL, and vector databases to support low-latency AI retrieval and inference workloads.
  • Cloud & Infrastructure: Leverage AWS, Kubernetes, and infrastructure-as-code (Terraform/CloudFormation) to build robust, production-ready AI platforms.
  • Performance & Reliability: Diagnose system bottlenecks, optimize for cost and speed, and ensure the reliability and fault-tolerance of AI-driven workflows.
  • Collaboration: Partner with ML researchers, platform engineers, and scientists to translate models and algorithms into scalable, production-ready systems.

What You’ll Need to Succeed

  • Educational Background: Bachelor’s or Master’s in Computer Science, Engineering, or a related field.
  • Backend & Data Expertise: 7+ years of professional experience building and scaling production systems, including APIs, data pipelines, and distributed services.
  • Programming Skills: Strong Python skills (FastAPI, Flask, Django), with solid experience in backend service development.
  • Databases: Proven experience with SQL, NoSQL, and vector databases; skilled in schema design, indexing, and query optimization.
  • Applied AI Systems: Hands-on experience integrating ML models or AI-driven workflows into production services.
  • Cloud & DevOps: Proficiency with AWS, Docker/Kubernetes, CI/CD pipelines, and infrastructure-as-code.
  • Communication & Problem-Solving: Ability to work cross-functionally with diverse teams and explain complex technical concepts to non-experts.

Bonus Points For

  • Scientific & Data-Intensive Domains: Experience working with life sciences, materials sciences, or other research-heavy fields.
  • Startup Experience: Comfort with fast-paced, iterative environments where impact and adaptability matter.

Compensation

We offer competitive base compensation with bonus potential and generous early-stage equity. Your final offer will reflect your background, expertise, and expected impact.

U.S. Benefits. Full-time U.S. employees receive a comprehensive benefits program including medical, dental, and vision coverage; employer-paid life and disability insurance; flexible time off with generous company wide holidays; paid parental leave; an educational assistance program; commuter benefits, including bike share memberships for office based employees; and a company subsidized lunch program.

International Benefits. Full-time employees outside the U.S. receive a comprehensive benefits program tailored to their region. USD salary ranges apply only to U.S.-based positions; international salaries are set to local market.

Expected Base Salary Range

$204,000—$310,000 USD

Source · Lila SciencesFirst seen 2 NovOriginal ↗