# Director, Program Management at Keros Therapeutics

> Hybrid · United States · Director+ · Other · open. Source: https://alderhq.app/jobs/greenhouse%3Akeros%3A4752027005 (read 2026-11-12).

## Facts (observed)

- Company: [Keros Therapeutics](https://alderhq.app/companies/keros-therapeutics)
- Location text: Lexington, MA (Hybrid); Lexington, MA (Hybrid)
- Where it can be done from (inferred): Hybrid · United States (evidence: "Location: Lexington, MA (Hybrid); Lexington, MA (Hybrid)")
- Posted: 2026-11-06 (5 days ago)
- First seen by alder: 2026-11-07 · last verified: 2026-11-08
- Reposted: 0 times · edited: 0 times
- Apply on the employer's site: https://kerostx.com/current-opportunities?gh_jid=4752027005

## Pay and sponsorship

- Posted pay: $201k–$239k per year (from the listing's pay field)
- Market band for similar posted roles (United States, n 5897): p25 $165k, median $210k, p75 $255k

## Description (the employer's text)

At Keros, our mission is to deliver significant clinical benefit to a wide range of patients with disorders that are linked to dysfunctional signaling of the transforming growth factor-beta (TGF-ß) family of proteins. With a focus on developing differentiated product candidates that are designed to alter TGF-β signaling, we aim to target the pathways critical for the growth, repair and maintenance of blood cells and a number of tissues, including bone, skeletal muscle, adipose and heart tissue. We believe our product candidates have the potential to unlock the full therapeutic benefits of modulating the TGF-β superfamily and provide disease-modifying benefit to patients.

### Job Summary

The Director, Program Management, will provide strategic and operational leadership for the rinvatercept (KER-065) development program. This individual will lead cross-functional program planning and execution as rinvatercept advances through clinical development. The ideal candidate will combine strong drug-development program leadership with meaningful experience running clinical trials across Phase 1, Phase 2 and Phase 3.

The successful candidate will move effectively between strategic planning and hands-on execution, anticipate and mitigate risks, drive timely decisions and maintain alignment across Clinical Development, Clinical Operations, Regulatory Affairs, CMC/Technical Operations, Nonclinical, Biometrics and other functions.

### Primary Responsibilities

Program Strategy and Leadership

- Serve as the program management lead for rinvatercept, partnering with functional leaders to define and execute the optimal global development strategy
- Lead the cross-functional program team, including representatives from Clinical Development, Clinical Operations, Regulatory Affairs, CMC/Technical Operations, Nonclinical, Biometrics, Medical Affairs, Commercial and Corporate Strategy
- Guide the program through proof of concept, registration-enabling studies, regulatory submissions and potential marketing authorization
- Translate development strategy into clear program objectives, operational priorities and measurable deliverables
- Mobilize and align the organization around the program strategy and drive timely decision-making through appropriate governance forums
- Balance day-to-day program execution with long-range strategic planning
Integrated Development Planning

- Create and maintain an integrated strategic development plan covering program goals, value-creation milestones, critical-path activities, cross-functional dependencies, timelines, decision points, assumptions, risks, alternative scenarios, budget and resource requirements
- Ensure functional plans are aligned with the overall development strategy and that interdependencies are clearly understood and actively managed
- Identify potential gaps, conflicts and constraints before they affect clinical, regulatory or operational milestones
- Lead scenario planning to evaluate alternative development approaches and their implications for timeline, resources, risk and program value
Clinical Development and Trial Execution

- Partner with Clinical Development and Clinical Operations to plan and execute rinvatercept clinical trials across Phase 1, Phase 2 and Phase 3
- Integrate clinical activities with regulatory, CMC, nonclinical, biometrics and other program workstreams
- Identify and manage dependencies affecting protocol development, regulatory submissions, site activation, patient enrollment, study conduct, data delivery and clinical readouts
- Support transitions between stages of development, including progression from early clinical studies into proof-of-concept and registration-enabling trials
- Apply an understanding of neuromuscular and rare-disease trial challenges, including specialized investigator sites, patient recruitment, natural-history considerations, endpoints and global execution
- Ensure clinical-trial plans are supported by realistic timelines, budgets, resources and risk-mitigation plans
Cross-Functional Team Effectiveness

- Establish and lead an effective operating cadence for program team meetings, working sessions and governance reviews

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Data: alder (https://alderhq.app). Cite https://alderhq.app/jobs/greenhouse%3Akeros%3A4752027005 and the date you read it. Observed facts come from the employer's own listing; location reach, level, family and skills are inferences.