About GenScript

Founded in 2002 in New Jersey, GenScript Biotech Corporation accelerates innovation in biotech and healthcare by providing researchers and companies with the building blocks needed to develop groundbreaking treatments and products. Guided by its mission to Make People and Nature Healthier Through Biotechnology, and its role as a well-recognized biotechnology company, GenScript has a team of approximately 6,165 employees and has served more than 200,000 customers across over 100 countries and regions.

Position Summary

GenScript is seeking a motivated and detail-oriented Research Associate, Analytical Development to support the development, qualification, and routine execution of analytical methods for RNA, lipids, lipid nanoparticles (LNPs), and related bioconjugates at our Seattle site.

The successful candidate will perform hands-on laboratory work across HPLC/UHPLC, LC-MS, nano flow cytometry, and RNA/LNP analytical testing. This role will support routine sample analysis, analytical method development and optimization, troubleshooting, and method transfer in close collaboration with R&D, QC, Production, and other cross-functional teams.

This position is well suited for a scientist who combines strong wet-lab skills with attention to detail, analytical thinking, and a desire to build technical expertise in emerging RNA and lipid nanoparticle technologies.

Key Responsibilities

1. Chromatography and Analytical Testing

Prepare RNA, oligonucleotide, lipid, LNP, antibody, and bioconjugate samples for analytical testing according to established procedures and experimental plans.
Perform HPLC/UHPLC analyses using UV and/or charged aerosol detection (CAD), including sample and standard preparation, instrument sequence setup, chromatogram review, peak integration, and initial data assessment.
Support chromatographic methods for evaluating RNA purity, lipid identity and purity, lipid composition, residual components, and related product-quality attributes.
Assist with preparative chromatography, fraction collection, sample tracking, and evaluation of purification fractions for RNA and related development projects.
Support analytical method development, optimization, troubleshooting, and transfer under the guidance of senior scientists and the group lead.

2. LC-MS Characterization

Support LC-MS characterization of RNA, oligonucleotides, synthetic cap analogs, and related materials.
Assist with characterization of attributes such as molecular identity, capping efficiency, and poly(A) characteristics, as appropriate to the method and project.
Perform sample preparation and assist with spectral review, data processing, and interpretation under scientific guidance.
Support troubleshooting of sample-preparation, chromatographic, mass-spectrometric, and data-processing issues.

3. RNA and LNP Analytical Development

Perform analytical testing to support characterization of mRNA, circRNA, oligonucleotides, lipids, LNPs, antibodies, and related bioconjugates, depending on project needs.
Support assays evaluating RNA attributes such as concentration, purity, integrity/fragmentation, aggregation, and residual process-related components.
Support characterization of LNP-related attributes, including lipid composition and purity and residual/free components associated with LNP conjugation or formulation processes.
Perform routine sample cleanup, dilution, buffer preparation, and analytical sample processing using appropriate RNase-free techniques.

4. Nano Flow Cytometry and Targeted LNP Characterization

Prepare fluorescently labeled samples, standards, and appropriate experimental controls for flow-cytometry analysis.
Perform routine flow cytometer setup, instrument QC, sample acquisition, and application of established analysis and gating strategies.
Support characterization of antibody-decorated or targeted LNPs, including evaluation of labeling and conjugation-related attributes where appropriate.
Assist with optimization and troubleshooting of flow-cytometry-based analytical workflows.