Company Overview

Dyne Therapeutics is focused on delivering functional improvement for people living with genetically driven neuromuscular diseases. We are developing therapeutics that target muscle and the central nervous system (CNS) to address the root cause of disease. The company is advancing clinical programs for Duchenne muscular dystrophy (DMD) and myotonic dystrophy type 1 (DM1) as well as preclinical programs for facioscapulohumeral muscular dystrophy (FSHD), Pompe disease and multiple DMD mutations. At Dyne, we are on a mission to deliver functional improvement for individuals, families and communities. Learn more at https://www.dyne-tx.com/, and follow us on X, LinkedIn and Facebook.

Role Summary

The Senior Manager, US Medical Affairs supports execution of Dyne’s US Medical Affairs strategy for the Duchenne Muscular Dystrophy (DMD) program. This role contributes to critical launch readiness activities and supports the planning and delivery of US Medical initiatives, including KOL engagement, congress execution, medical education efforts, and cross-functional coordination.

The Senior Manager operates as both a scientific and operational contributor, helping prepare the US Medical organization for anticipated DMD program needs. This role partners closely with Medical Science Liaisons (MSLs), Global Medical Affairs, and cross-functional stakeholders to ensure medical activities are high-quality, compliant, and impactful.

This role is based in Waltham, MA.

Primary Responsibilities Include:

Medical Strategy Execution & Launch Readiness

Supports execution of US Medical Affairs tactical plans for the DMD program
Assists in implementing scientific platform materials, congress planning, and medical education initiatives
Contributes to cross-functional launch readiness activities to ensure alignment with program milestones
Supports development and deployment of DMD-focused scientific materials, disease state education resources, and field medical tools

Field Medical & KOL Engagement

Partners with the US MSL team to support KOL identification, engagement planning, insight gathering, and field metric tracking
Translates field insights into actionable recommendations for Medical Affairs and cross-functional teams
Tracks and monitors field activity and engagement effectiveness

Scientific Materials & Medical Review

Contributes to development of scientific materials, field tools, and educational content
Provides Medical review for promotional materials through the Promotional Review Committee (PRC)
Maintains deep and current scientific knowledge in DMD and Dyne’s therapeutic platform

Congress & External Engagements

Supports planning and execution of medical congresses, including onsite activities aligned to DMD milestones
Coordinates logistics and execution of US advisory boards and expert engagements

Cross-Functional Collaboration & Compliance

Partners with Patient Advocacy, Market Access, and Commercial teams to support aligned medical activities
Ensures all activities comply with US regulatory, legal, and compliance standards
Models Dyne’s core values through collaboration, accountability, and scientific integrity

Education and Skills Requirements:

Advanced scientific or clinical degree required (PhD, PharmD, MD, or equivalent)

7+ years of relevant Medical Affairs experience in pharmaceutical or biotechnology industry

Rare disease experience preferred; neuromuscular disease experience a plusExperience supporting US-based medical tactics, congress activities, or field medical programs

Strong scientific acumen with ability to translate clinical data for diverse audiences

Excellent written and verbal communication skills

Ability to operate effectively in a fast-paced, evolving environment with competing priorities

Demonstrated ability to build collaborative relationships with internal and external

to travel up to 25%, including occasional overnight and weekend travel

Positive team orientation with strong alignment to Dyne’s Core Values

Passion for improving the lives of patients with neuromuscular diseases