AI Biologist - Proteomics

Latch builds rigorous scientific benchmarks (benchmarks.bio) for AI agents across biology. We work with frontier labs and pharma to measure whether agents can handle real biological workflows: the messy, multi-layer reasoning that matters in the field.

We’re seeking an AI Biologist to join our Proteomics team, pushing what AI can achieve across proteomics, lipidomics, and metabolomics.

About the Role. You will be the scientific authority on ground truth, testing whether agents can reason like an expert mass spectrometrist. AI agents today struggle to interrogate raw mass spec data, separate real biological signal from artifacts of sample prep, instrument behavior, and processing, and reach conclusions an expert would stand behind. You will work with software engineers and scientists to build the tasks and datasets behind our proteomics benchmarks, and over time lipidomics and metabolomics. Your judgment will set the standard agent outputs are held to, including:

Build the task

Define what expert reasoning looks like for a mass spec question, and write gold-standard answers with the rationale an experienced mass spectrometrist would defend

Design realistic scenarios across the workflow: sample prep, acquisition, identification, quantification, and biological interpretation

Curate mass spec datasets across proteomics, lipidomics, and metabolomics, alongside antibody-based and sequencing data where relevant

Partner with software engineers to turn your judgment into new workflows

Set the hard calls

Test whether agents can tell true biological signal from batch effects, contamination, poor identifications, or processing artifacts

Adjudicate ambiguous results: decide what the data supports, what it doesn’t, and which experiment would settle the question

Judge the agent

Interrogate agent reasoning step by step, and challenge conclusions that sound right but wouldn’t survive lab meeting or peer review

Pinpoint where agents go wrong, what an expert would do instead, and what evidence would change the call

Score agent confidence, rewarding explicit uncertainty over overconfident calls

Requirements

PhD in proteomics, analytical chemistry, biochemistry, or a related field

Hands-on mass spectrometry experience with first-hand data analysis and a publication record

Mass spec experience beyond proteomics alone: lipidomics or metabolomics strongly preferred

Strong command of experimental design and statistics

AI-ready from day one: daily use of Claude, Cursor, or similar agents, with the judgment to spot where model reasoning is technically correct but scientifically unsound

Confidence to overrule an AI agent when the evidence demands it, and the openness to update when shown wrong

Bonus: protein sequencing or antibody experience

Culture @ Latch

We practice radical transparency: you’ll know how the company is doing, what’s working, and what isn’t. It’s always us against the problem, never each other. We’re opinionated but respectful of each other’s time, and we think through possible solutions before bringing a problem to anyone. We use AI constantly, so we reward original expert judgment, not AI output passed off as your own. You’ll start on the bench that fits your expertise and can move across teams as you build a track record.

Outside of work: company outings most months, team off-sites, and a community that does cycling, soccer, figure skating, boxing, running, martial arts, music, books, and game nights.

Compensation & Logistics

Pay: $140K–$180K OTE (on-target earnings), with no ceiling.

Your pay is your OTE times your weekly quota attainment. Hit quota, earn your OTE; double it, earn double. Example: $150K OTE at double quota = $300K.

Your first 4 weeks (ramp) are paid at full OTE while we train you.

You’re paid full OTE whenever quota can’t fairly apply: when a new project is starting, the platform goes down, or we pull you onto a special project.

In the US: full-time W-2

Guaranteed base set by your state, paid every paycheck no matter what

Health, dental, vision: 100% covered for you, 50% for dependents