We are a vibrant and intensely mission-driven team in San Francisco, comprising members from MIT, Harvard Medical School, Roche, ETH, and Dana-Farber.

We value speed and rigor, coupled with excitement, drive, and a strong work ethic. In an early-stage environment, we value people who can bring clarity to open-ended problems, take ownership of the next steps, and follow through with energy.

Capable Labs is a place for ambitious, high-integrity people who want to become dramatically better. You will be surrounded by people who care intensely about the work, get close feedback from the people making scientific and company-defining decisions, and have room to own increasingly important problems.

We believe excellent work should be met with meaningful reward, ownership, and trust. Responsibility is earned through contribution, not title alone: anyone who demonstrates the judgment, rigor, and follow-through to move important work forward can earn meaningful scope.

About the Role

You will run organic-chemistry workflows on a dedicated night-shift schedule so compounds are ready for characterization, biological testing, or handoff the next day. You will execute solution- and solid-phase chemistry, solve experimental problems independently, maintain complete records, and give the day team a clear account of every result and open issue.

Responsibilities

Execute overnight synthesis workflows, including route planning, reaction setup, workup, purification, characterization, and sample preparation.

Run and troubleshoot organic reactions involving functional-group transformations, coupling chemistry, protecting-group strategies, late-stage diversification, and parallel synthesis.

Use solution-phase and solid-phase methods where appropriate, including cleavage, deprotection, crude analysis, purification, and final quality control.

Resolve overnight issues involving low conversion, poor selectivity, side products, decomposition, solubility, purification, recovery, and instrument downtime.

Purify and characterize compounds using analytical HPLC, prep HPLC, LC-MS, NMR, flash chromatography, SFC, and related methods as appropriate.

Prepare compounds for in vitro and in vivo testing and maintain accurate experimental and batch-level quality-control records.

Provide clear morning handoffs covering completed work, results, failures, sample locations, risks, and follow-up actions.

Ideal Qualifications

Able and willing to work the designated night-shift schedule reliably and operate independently when needed.

Hands-on synthetic chemistry experience and strong experimental discipline.

Interest in owning overnight chemistry from reaction execution through purification, characterization, documentation, and sample handoff.

A creative, fast, rigorous, and safety-conscious approach to laboratory problem-solving.

Sound judgment when a reaction fails, an instrument is down, data look unusual, or the usual day-team contact is unavailable.

The ability to maintain excellent records and create clean, useful handoffs across night and day teams.

Pay & Benefits

Compensation and equity will depend on the skills, experience, and scope of impact you bring. We are open to a conversation based on the scope and impact you could bring.

$500+ monthly wellness budget for training, supplements, coaching, recovery, or other tools that help you perform at your best.

Healthcare: We offer a broad range of medical, dental, and vision coverage options, with Capable covering 100% of the base policy.

You will also have access to HSA, FSA, and 401K plans.

Healthy vegetarian dinners with the team are provided daily.

We support visa sponsorship where appropriate, including O-1, H-1B, J-1, TN, and other employment-based pathways. Our team is already international, with members from Canada, Pakistan, Germany, Austria, Switzerland, China, India, and the United States.

Application Process

Our process is fast, transparent, and personal. We care about getting to know the person behind the application.

Initial application

First phone screen