# (Senior / Principal) Scientist, Medicinal Chemistry at Capable > Onsite · United States · Principal · Software engineering · open. Source: https://alderhq.app/jobs/ashby%3ACapable%3Ac38cffdb-4fc5-4ce6-8c66-d8c8bad06010 (read 2026-11-08). ## Facts (observed) - Company: [Capable](https://alderhq.app/companies/capable) - Location text: San Francisco - Where it can be done from (inferred): Onsite · United States (evidence: "Location: San Francisco") - Posted: 2026-09-02 (67 days ago) - First seen by alder: 2026-11-04 · last verified: 2026-11-07 - Reposted: 0 times · edited: 0 times - Apply on the employer's site: https://jobs.ashbyhq.com/Capable/c38cffdb-4fc5-4ce6-8c66-d8c8bad06010 ## Pay and sponsorship - Posted pay: not posted - Market band for similar posted roles (SF Bay Area, n 195): p25 $226k, median $270k, p75 $320k ## Description (the employer's text) We are a vibrant and intensely mission-driven team in San Francisco, comprising members from MIT, Harvard Medical School, Roche, ETH, and Dana-Farber. We value speed and rigor, coupled with excitement, drive, and a strong work ethic. In an early-stage environment, we value people who can bring clarity to open-ended problems, take ownership of the next steps, and follow through with energy. Capable Labs is a place for ambitious, high-integrity people who want to become dramatically better. You will be surrounded by people who care intensely about the work, get close feedback from the people making scientific and company-defining decisions, and have room to own increasingly important problems. We believe excellent work should be met with meaningful reward, ownership, and trust. Responsibility is earned through contribution, not title alone: anyone who demonstrates the judgment, rigor, and follow-through to move important work forward can earn meaningful scope. ### About the Role You will lead medicinal-chemistry design and synthesis across Capable’s therapeutic programs, deciding which compounds to make and translating SAR and biological data into the next design cycle. You will remain hands-on from route selection through purification and characterization while owning the chemistry decisions that improve potency, selectivity, stability, exposure, tolerability, and efficacy. ### Responsibilities Lead compound design and synthesis across small-molecule, peptide, and peptide-adjacent programs, from target-compound selection through biological handoff. Use SAR, in vitro, and in vivo data to prioritize and design next-round compounds. Design and execute practical synthetic routes using solution-phase or solid-phase workflows, functional-group transformations, coupling chemistry, protecting groups, and late-stage diversification as appropriate. Own synthesis, purification, characterization, quality control, documentation, and preparation of compounds for biological testing. Operate and help maintain key chemistry instrumentation, including HPLC, prep HPLC, LC-MS, microwave-assisted synthesis systems, and related analytical or purification platforms. Resolve difficult synthetic and analytical issues involving failed reactions, selectivity, side products, solubility, purification, recovery, or instrument performance. Partner closely with biology and pharmacology teams to connect chemistry decisions to potency, selectivity, stability, exposure, tolerability, and efficacy. ### Ideal Qualifications Five or more years of hands-on industry experience in medicinal or synthetic organic chemistry; peptide experience is helpful but not required. Strong medicinal-chemistry judgment and the ability to use SAR and biological data to decide what to make next. Experience owning chemistry end to end, including compound design, route selection, synthesis, purification, characterization, quality control, and biological handoff. Deep troubleshooting ability and a high bar for clean experimental execution and documentation. Comfort working close to biological readouts and balancing potency, selectivity, stability, exposure, tolerability, efficacy, and practical synthesis. The ability to provide technical direction and raise the quality of a program while remaining hands-on. ### Pay & Benefits Compensation and equity will depend on the skills, experience, and scope of impact you bring. We are open to a conversation based on the scope and impact you could bring. $500+ monthly wellness budget for training, supplements, coaching, recovery, or other tools that help you perform at your best. Healthcare: We offer a broad range of medical, dental, and vision coverage options, with Capable covering 100% of the base policy. You will also have access to HSA, FSA, and 401K plans. Healthy vegetarian dinners with the team are provided daily. We support visa sponsorship where appropriate, including O-1, H-1B, J-1, TN, and other employment-based pathways. Our team is already international, with members from Canada, Pakistan, Germany, Austria, Switzerland, China, India, and the United States. --- Data: alder (https://alderhq.app). Cite https://alderhq.app/jobs/ashby%3ACapable%3Ac38cffdb-4fc5-4ce6-8c66-d8c8bad06010 and the date you read it. Observed facts come from the employer's own listing; location reach, level, family and skills are inferences.